The Role Of Haematopoietic Stem Cell Transplantation And...

Discuss the role of haematopoietic stem cells in transplantation and curing disease 1. Hematopoietic stem cells Till and McCulloch described the two hallmarks of Haematopoietic stem cells to be long term self-renewal and the ability to differentiate into all various types of specialized blood cells, with one stem cell able to produce around a million mature blood cells after 20 divisions. The differentiation of these stem cells result in committed hemopoitic progenitor cells which give rise to cells from both the myeloid (monocytes, macrophages,neutrophils, basophils,eosinophils, erythrocytes, mega-karyocytes, platelets and dendritic cells) and lymphoid lineage (T-cells and NK-cells). 2. Hematopoietic stem cell transplantation Tissue engineering is a type of regenerative medicine which aims to replace damaged tissue with new tissue able to resume function and repair structure of normal tissue. Hematopoietic stem cell transplantation was the first type of tissue engineering using stem cells. Hematopoitictic stem cells are infused into the host to treat many blood based disorders including cancers, blood diseases and immunodefiencies. There is a standard procedure for the infusion of these cells, however variations in the relationship between donor and recipient and source of hematopoietic stem cells do cause some variability in the process. 3. Donor/host relationship There are three distinct forms of donor/host relationships involved in HSCT, autologous, allogenic andShow MoreRelatedEssay on Stem Cell Research: Scientific Advancement vs. Human Rights2939 Words   |  12 PagesIntroduction to Stem Cells As improvements in scientific technology and techniques allow for better observations and insights into the natural world, so to do advancements in medical research occur on a seemingly daily basis. On such research topic that has found itself the center of a global debate is the issue of stem cell research. Hailed by some as one of the most dynamic areas of research ever to exist, it is thought to be the next big â€Å"revolution† in medicine, surpassing even the advent